The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression.

The effect of chronic treatment with lurasidone on rat liver cytochrome P450 expression and activity in the chronic mild stress (CMS) model of depression

Lurasidone Exerts Antidepressant Properties in the Chronic Mild Stress Model through the Regulation of Synaptic and Neuroplastic Mechanisms in the Rat Prefrontal Cortex

BACKGROUND Major depression is associated with several alterations, including reduced neuronal plasticity and impaired synaptic function, which represent an important target of pharmacological intervention. METHODS In the present study, we have investigated the ability of the antipsychotic drug lurasidone to modulate behavioral and neuroplastic alterations in the chronic mild stress model of ...

Investigating the Lethal Effects of Lead Chloride (PbCl2) on Blood Indices, Liver Enzymes and Evaluation on Cytochrome P450 Gene Expression in Common Carp (Cyprinus carpio)

The aim of this study was to investigate the sub-lethal effects Lead Chloride (PbCl2) on blood indices, liver enzymes, cytochrome P450 gene expression in common carp. For this purpose, Fish with a mean weight of 7 33±0.33 g were prepared and divided into 3 treatments and a control group and exposed to effective concentrations (0.05, 0.15, 0.25 mg / l) of sublethal toxicity for a period of 14 da...

Effect of Chronic Restraint Stress on HPA Axis Activity and Expression of BDNF and Trkb in the Hippocampus of Pregnant Rats: Possible Contribution in Depression during Pregnancy and Postpartum Period

Introduction: Brain-Derived Neurotrophic Factor (BDNF) and its receptor, TrkB, in the hippocampus are targets for adverse effects of stress paradigms in addition, BDNF and its receptor play key role in the pathology of brain diseases like depression. In the present study, we evaluated the possible role of hippocampal BDNF in depression during pregnancy, Methods: To achieve the purpose, repeat...

Evaluation of CYP2C9 activity in rats: use of tolbutamide alone and in combined with bupropion

A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...